The research done in the Lewis Lab has been highly cited and influential.
In June 2017, Dr. Lewis’ Google Scholar h-index was 104.
Interviews on Schizophrenia Research
Charlie Rose Brain Series: Schizophrenia As part of the Charlie Rose Brain Series, with co-host Dr. Kandel, Dr. Lewis and a panel of other scientists discuss schizophrenia, its treatments, and current research.
Schizophrenia: The Making of a Troubled Mind. David Dobs asks “where does one begin and the other end” in relation to schizophrenia research. The News Feature reviews the importance of the Lewis Lab’s work.
In Cold Springs Harbor Laboratory’s Genes to Cognition Online, Dr. Lewis briefly discusses current research on each of the following topics related to schizophrenia.
SCHIZOPHRENIA AND ALTERATIONS IN THE BRAIN
Schizophrenia is underlined by subtle changes in multiple regions in the brain.
NEURAL STRUCTURES AND SCHIZOPHRENIA
The diversity of symptoms in schizophrenia is reflected in the diversity of genetic and neural causes of the disorder.
POSITIVE AND NEGATIVE SYMPTOMS
The symptoms of schizophrenia are typically defined as either positive or negative.
Individuals with schizophrenia can have coordination problems, which may relate to impaired neural circuits.
CURRENT PHARMACOLOGICAL TREATMENT
The positive symptoms of schizophrenia are currently more treatable than the negative symptoms.
FIRST AND SECOND GENERATION DRUG TREATMENTS
Dr. Lewis explains the difference between first and second generation drug treatments for schizophrenia.
DRUG TREATMENT RESPONSE
Many schizophrenic individuals respond well to anti-psychotic medication. Treatment for other symptoms is developing.
ANIMAL MODELS OF SCHIZOPHRENIA
Although many symptoms of schizophrenia are not reproducible in animals, animal models can help understand the disorder.
GENETIC MODELS IN ANIMALS
Model organisms such as mice can help uncover the interplay of the genetic components in schizophrenia.
SCHIZOPHRENIA VS. BIPOLAR DISORDER
Dr. Lewis discusses the differences between schizophrenia and bipolar disorder, noting that there may be some shared risk factors.
COGNITIVE DISTURBANCES (EXECUTIVE ERRORS) IN SCHIZOPHRENIA
Executive dysfunction (an inability to exert control over behavior) is a major cognitive symptom of schizophrenia.
Laboratory of David A. Lewis, MD
Researching the neural circuitry of the prefrontal cortex and related brain regions, and the alterations of this circuitry in schizophrenia.
© 2017 University of Pittsburgh
Western Psychiatric Institute and Clinic
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